On the .22 front, I picked up a Ruger MkIII 22/45 - basically one of the most reliable .22 pistols ever made with a 1911-ish interface. The best of both worlds. It's not small, but if I were to pack for self defense, I wouldn't pick a .22 - my 9mm would be strapped to my bod.

Pic of my 22/45: